Pre-plated libraries

Natural Compound Library

The Greenpharma natural chemical library combines our expertise in computational and medicinal chemistry, and our knowledge in pharmacognosy to create a unique source of diverse and pure compounds for hit/lead discovery. To built GPN, we gathered 150,000 natural compound structures in a database and used chemoinformatic tools to select a subset of chemically diverse and drug-like compounds. We discarded amino acids, peptides, nucleic acids, long fatty chains, metals. We, then, carefully selected different phytochemical families in order to have as much family representatives as possible. A stock is maintained for each molecule to ensure further resupplies. GPN compounds are certified genuine natural compounds and information about the sources (e.g. family, genus, species, organ) are provided.

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Applications

Hit & lead discovery, chemogenomics

Benefits

Large chemical diversity, drug-like molecules, possibility of resupplies.

Library technical characteristics

Each microplate of this library is populated with 80 products. Each well contains 200µL of a DMSO solution at 2mg/mL of the products. Taking into account the average molecular weight, we estimate at about 5.10-3 M the concentration in each well. This high concentration easily allows dilutions up to micromolar concentrations without the side toxicity effect of DMSO.

  • Purity above 90 %
  • Chemical diversity
  • Drug-likeness
  • User-defined formatting in option

Data provided

The library is supplied with an electronic file (e.g. SDF, XML, HTML, PDF format) containing the structure, the name, the position of each product in the microplate, examples of natural sources producing the compounds and calculated physico-chemical descriptors